| Sebastian Bach | Dr. Henry Jekyll | |
| Edward Hyde Jekyll's "other half" | ||
| Anastasia Barzee | Emma Carew Jekyll's fiance | |
| Robert DuSold | Rupert Bishop of Basingstoke | |
| Robert Evan | Dr. Henry Jekyll | |
| Edward Hyde Jekyll's "other half" | ||
| Merwin Foard | Mr. Simon Stride | |
| Erika Greene | Molly a fish gutter | |
| David Hasselhoff | Dr. Henry Jekyll | |
| Edward Hyde Jekyll's "other half" | ||
| Leah Hocking | Lucy | |
| Peter Johl | Doctor | |
| Lord G | ||
| Poole Jekyll's manservant | ||
| Joseph Mahowald | Dr. Henry Jekyll | |
| Edward Hyde Jekyll's "other half" | ||
| Stuart Marland | Barrow Boy | |
| General Lord Glossop | ||
| Policeman | ||
| Siegfried the Pianist at "The Red Hat" | ||
| Luba Mason | Lucy | |
| Corinne Melançon | Alice a scullery maid | |
| Housemaid | ||
| Nurse | ||
| Whore | ||
| Kelli O'Hara | Kate a cockle seller | (Jul 20, 2000-Jan 7, 2001) |
| Max Perlman | Ensemble | (May 1999-Aug 1999) |
| Mike a clerk | (May 1999-Aug 1999) | |
| Andrea Rivette | Emma Carew Jekyll's fiance | |
| John Schiappa | Mental Patient | |
| Ned a sailor | ||
| Coleen Sexton | Lucy | |
| Kate Shindle | A Young Girl managed by Gwinny | |
| Bet a scullery maid | ||
| Bridesmaid | ||
| Housemaid | ||
| Nurse | ||
| Jodi Stevens Wednesday and Saturday matinees | Lucy | Alternate |
| Kay Story | A Young Girl managed by Gwinny | |
| Bet a scullery maid | ||
| Bridesmaid | ||
| Housemaid | ||
| Nurse | ||
| Christy Tarr | Kate a cockle seller | |
| Jack Wagner | Dr. Henry Jekyll | |
| Edward Hyde Jekyll's "other half" | ||
| Rod Weber | A Newsboy | |
| Bill a docker |