| Karmine Alers | Mimi Marquez | |
| Christian Anderson | Mark Cohen | |
| Mayumi Ando Broadway debut | Alexi Darling, Roger's mom, and others | |
| Sebastian Arcelus | Roger Davis | |
| Maggie Benjamin Broadway debut | Maureen Johnson | |
| Mark's mom, and others | ||
| Declan Bennett | Roger Davis | (Oct 8, 2007 - ?) |
| Carla Bianco | Maureen Johnson | |
| Richard H. Blake | Roger Davis | |
| Jessica Boevers | Mark's mom, and others | |
| Maureen Johnson | ||
| Rufus Bonds, Jr. | Tom Collins | |
| Melanie Janine Brown Broadway debut | Mimi Marquez | (Apr 19, 2004-May 31, 2004) |
| Haven Burton Broadway Debut | Mark's mom, and others | |
| Norbert Leo Butz | Roger Davis | |
| Matt Caplan | Mark Cohen | (? - Aug 6, 2006) |
| Jodi Carmeli Broadway debut | Mark's mom, and others | |
| T.V. Carpio | Ensemble | |
| Will Chase Broadway debut | Steve, man with squeegee, a waiter, and others | |
| Roger Davis | ||
| Luther Creek | Roger Davis | |
| Ensemble | ||
| Gordon, the man, Mr. Grey, and others | ||
| Wilson Cruz | Angel Schunard | |
| Krysten Cummings | Mimi Marquez | |
| Merle Dandridge | Joanne Jefferson | |
| Frenchie Davis | Mrs. Jefferson, woman with bags, and others | (May 16, 2003 - ?) |
| Mrs. Jefferson, woman with bags, and others | (Jun 1, 2004 - ?) | |
| Maya Days | Mimi Marquez | |
| Aisha de Haas | Mrs. Jefferson, woman with bags, and others | |
| Robin De Jesús Broadway Debut | Steve, man with squeegee, a waiter, and others | |
| Shelley Dickinson | Mrs. Jefferson, woman with bags, and others | |
| Tonya Dixon | Joanne Jefferson | |
| D'Monroe | Benjamin Coffin III | |
| Shaun Earl | Angel Schunard | |
| Ensemble | ||
| Paul, a cop, and others | ||
| Amy Ehrlich Broadway debut | Mark's mom, and others | |
| Trey Ellett Broadway debut | Mark Cohen | |
| Eden Espinosa | Maureen Johnson | (May 30, 2008 - ?) |
| Cristina Fadale | Maureen Johnson | |
| Joey Fatone Broadway debut | Mark Cohen | (Aug 5, 2002-Dec 22, 2002) |
| Mark Richard Ford Broadway debut | Tom Collins | |
| Ava Gaudet Broadway Debut | Maureen Johnson | |
| Robert Glean | Paul, a cop, and others | |
| Reneé Elise Goldsberry | Mimi Marquez | |
| Andrea Goss | Alexi Darling, Roger's mom, and others | |
| Tamyra Gray | Mimi Marquez | (May 29, 2007-Nov 25, 2007) |
| Danielle Lee Greaves | Joanne Jefferson | |
| Christopher J. Hanke | Mark Cohen | (Aug 7, 2006 - ?) |
| Colin Hanlon | Gordon, the man, Mr. Grey, and others | |
| Marcy Harriell | Mimi Marquez | |
| Nicolette Hart | Maureen Johnson | |
| Rodney Hicks | Benjamin Coffin III | |
| Troy Horne | Tom Collins | |
| Tim Howar | Roger Davis | |
| Scott Hunt | Steve, man with squeegee, a waiter, and others | |
| Sala Iwamatsu | Alexi Darling, Roger's mom, and others | |
| Mark Leroy Jackson Broadway debut | Tom Collins | |
| Marcus Paul James Broadway debut | Christmas caroler, Mr. Jefferson, a pastor and others | |
| Stu James Broadway debut | Benjamin Coffin III | |
| Harley Jay | Mark Cohen | (Oct 8, 2007 - ?) |
| Trisha Jeffrey | Mrs. Jefferson, woman with bags, and others | |
| Justin Johnston Broadway debut | Steve, man with squeegee, a waiter, and others | |
| Angel Schunard | ||
| Owen Johnston II | Steve, man with squeegee, a waiter, and others | |
| Catrice Joseph | Mrs. Jefferson, woman with bags, and others | |
| Adam Kantor Broadway debut! | Mark Cohen | |
| Kelly Karbacz | Maureen Johnson | |
| Kristen Lee Kelly | Mark's mom, and others | |
| Maureen Johnson | (Dec 30, 1997-Sep 1998) | |
| Jamie Lee Kirchner | Mimi Marquez | |
| Jeremy Kushnier | Roger Davis | (Nov 17, 2003 - ?) |
| Drew Lachey | Mark Cohen | (Sep 10, 2004-Mar 11, 2005) |
| Tracey Langran | Mark's mom, and others | |
| Anika Larsen | Ensemble | (Jul 5, 2000 - ?) |
| Alia León | Joanne Jefferson | |
| Telly Leung | Steve, man with squeegee, a waiter, and others | (Nov 20, 2006 - ?) |
| Nicole Lewis | Joanne Jefferson | |
| Ryan Link Broadway debut | Roger Davis | (Sep 8, 2003-Nov 10, 2003) |
| Roger Davis | (Jan 4, 2004-Feb 1, 2004) | |
| Jose Llana | Angel Schunard | |
| Caren Lyn Manuel | Mark's mom, and others | |
| Tracy McDowell | Mark's mom, and others | |
| Michael McElroy | Tom Collins | |
| Alan Mingo Jr. | Tom Collins | |
| Matthew Murphy | Steve, man with squeegee, a waiter, and others | |
| Darryl Ordell Broadway debut | Paul, a cop, and others | |
| Tina Ou | Alexi Darling, Roger's mom, and others | |
| Destan Owens | Christmas caroler, Mr. Jefferson, a pastor and others | |
| Tom Collins | ||
| Tom Collins | (Aug 11, 2008-Aug 17, 2008) | |
| Adam Pascal | Roger Davis | (Jul 30, 2007-Oct 7, 2007) |
| Todd E. Pettiford | Christmas caroler, Mr. Jefferson, a pastor and others | |
| Swing | ||
| Tamara Podemski | Maureen Johnson | |
| Manley Pope Broadway debut | Roger Davis | |
| Jim Poulos | Mark Cohen | |
| Steve, man with squeegee, a waiter, and others | ||
| Kenna J. Ramsey | Joanne Jefferson | |
| Anthony Rapp | Mark Cohen | (Jul 30, 2007-Oct 7, 2007) |
| Chad Richardson Broadway debut | Gordon, the man, Mr. Grey, and others | |
| Enrico Rodriguez | Steve, man with squeegee, a waiter, and others | |
| Jai Rodriguez Broadway debut | Angel Schunard | |
| Angel Schunard | (Jul 5, 2004-Jul 17, 2004) | |
| Angel Schunard | (Aug 2, 2004-Aug 14, 2004) | |
| Nick Sanchez | Paul, a cop, and others | |
| Sherie Scott | Maureen Johnson | |
| Andy Seńor Broadway debut | Angel Schunard | |
| Mark Setlock | Gordon, the man, Mr. Grey, and others | |
| Cary Shields Broadway debut | Roger Davis | |
| Antonique Smith | Mimi Marquez | |
| Jacques C. Smith | Benjamin Coffin III | |
| Peter Matthew Smith | Gordon, the man, Mr. Grey, and others | |
| Gwen Stewart | Joanne Jefferson | |
| Mrs. Jefferson, woman with bags, and others | (Nov 15, 2003 - ?) | |
| Mrs. Jefferson, woman with bags, and others | (Apr 29, 2007-May 27, 2007) | |
| Mrs. Jefferson, woman with bags, and others | (Jul 21, 2008 - ?) | |
| Yuka Takara | Alexi Darling, Roger's mom, and others | |
| Carly Thomas | Mark's mom, and others | |
| Tracie Thoms | Joanne Jefferson | (Jul 26, 2008-Sep 7, 2008) |
| Kim Varhola Broadway debut | Alexi Darling, Roger's mom, and others | |
| Loraine Velez | Mimi Marquez | |
| Natalie Venetia Belcon | Joanne Jefferson | |
| Tony Vincent | Mark Cohen | |
| Krystal L. Washington | Mimi Marquez | (May 16, 2003 - ?) |
| Myiia Watson-Davis Broadway debut | Joanne Jefferson | |
| Jay Wilkison | Gordon, the man, Mr. Grey, and others | |
| Maia Nkenge Wilson Broadway debut | Mrs. Jefferson, woman with bags, and others | |
| Joanne Jefferson |