| Henry Barnard | Young Collector | |
| Sandy Campbell | Young Collector | |
| Uta Hagen Played the part during Jessica Tandy's vacation; she later took the show on tour with Anthony Quinn, then back to Broadway | Blanche Du Bois | |
| Hilda Haynes | Negro Woman | |
| Wright King Broadway debut | Young Collector | |
| George Mathews | Harold Mitchell "Mitch" | |
| Ralph Meeker | Stanley Kowalski | |
| James O'Neill | Strange Man | |
| Jack Palance Played the part when Marlon Brando broke his nose and couldn't go on | Stanley Kowalski | |
| Carmelita Pope | Stella Kowalski | |
| Anthony Quinn Played the part during Marlon Brando's vacation; he later took the show on tour with Uta Hagen, then back to Broadway | Stanley Kowalski | |
| Mary Welch | Stella Kowalski |