| Cindy Adams | Narrator | (Dec 4, 2001-Dec 9, 2001) |
| Yassmin Alers | Phantom | |
| Sebastian Bach | Riff Raff | (Oct 30, 2001 - ?) |
| Dick Cavett | Narrator | (Jul 10, 2001-Sep 23, 2001) |
| Narrator | (Oct 30, 2001-Nov 11, 2001) | |
| Narrator | (Dec 25, 2001-Jan 6, 2001) | |
| Kate Clinton During Dick Cavett's vacation week | Narrator | (Jul 2, 2001-Jul 8, 2001) |
| Rosa Curry | Phantom | (2001-Jan 6, 2002) |
| Ana Gasteyer | Columbia | (Jun 12, 2001-Aug 19, 2001) |
| Usherette | (Jun 12, 2001-Aug 19, 2001) | |
| Gilbert Gottfried | Narrator | (Nov 13, 2001-Nov 18, 2001) |
| Dave Holmes | Narrator | (Nov 20, 2001-Nov 25, 2001) |
| Kristen Lee Kelly | Columbia | (Aug 21, 2001-Sep 23, 2001) |
| Janet Weiss | (Oct 30, 2001 - ?) | |
| Liz Larsen | Columbia | (Oct 30, 2001 - ?) |
| Robin Leach | Narrator | (Nov 6, 2001-Nov 11, 2001) |
| Daniel C. Levine | Phantom | |
| Terrence Mann | Frank 'N' Furter | (Aug 30, 2001 - ?) |
| John Jeffrey Martin | Brad Majors | |
| Matthew Morrison | Phantom | |
| Jim Osorno | Phantom | |
| Penn & Teller | Narrator | (Dec 18, 2001-Dec 23, 2001) |
| Luke Perry During Jarrod Emick's vacation | Brad Majors | (Jun 26, 2001-Aug 5, 2001) |
| Mark Price | Riff Raff | |
| Sally Jessy Raphael | Narrator | (Dec 11, 2001-Dec 16, 2001) |
| Jonathan Sharp | Rocky | (Oct 30, 2001 - ?) |
| Asa Somers | Phantom | |
| Jerry Springer | Narrator | (Nov 27, 2001-Dec 2, 2001) |
| Jason Wooten | Phantom | |
| Riff Raff | (Sep 4, 2001-Sep 23, 2001) | |
| Dr. Scott | (Oct 30, 2001 - ?) | |
| Eddie | (Oct 30, 2001 - ?) |